Abstract Background Ligand-binding proteins play key roles in many biological processes.Identification of protein-ligand binding residues is important in understanding the biological functions of proteins.Existing computational methods can be roughly categorized as sequence-based or 3D-structure-based methods.All these methods are based on traditio
Abstract Background Forkhead box L2 (FOXL2) is a transcription factor from the forkhead box family primarily expressed in the pituitary, ovaries, and eyelids.Human mutations in FOXL2 cause blepharophimosis, ptosis, epicanthus and inversus syndrome (BPES), which can be associated with primary ovarian insufficiency, and is indirectly linked with diff
Abstract Background In recent decades, China has experienced tremendous economic growth and also witnessed growing socioeconomic-related health inequality.The study aims to explore the potential causes of socioeconomic-related health inequality in urban and rural areas of China over the past two decades.Methods This study used six waves of the Chin
Conceptual metaphor economy is a patient in the newspaper discourse before recession will be analyzed in accordance to the viewpoints of conceptual metaphor theory.Corpus of research is composed of articles from the British magazine The Economist which deal with events in the world Linear Actuator economy and business in the period 2000-2006.We sha
Current global riverine flood risk studies assume a constant mean sea level boundary.In reality high sea levels can propagate up a river, impede high river discharge, thus leading to elevated water levels.Riverine flood risk in deltas may therefore be underestimated.This paper presents the first global scale assessment of the joint influence of riv